CB1 Receptors in the Anterior Piriform Cortex Control Odor Preference Memory
نویسندگان
چکیده
منابع مشابه
Odor-intensity coding in the anterior piriform cortex.
The primary olfactory cortex is defined as the region that receives direct fiber projection from the olfactory bulb (OB). The piriform cortex (PC) is the largest structure in the olfactory cortex. However, no ‘point to point’ anatomical connection between the OB and PC has been found (Haberly, 1998). In addition, no evidence that neurons with similar odorant preferences are located in a cluster...
متن کاملTitle: a Role for the Anterior Piriform Cortex in Early Odor Preference Learning: Evidence for Multiple
29 cFos activation in the anterior piriform cortex (aPC) occurs in early odor preference learning in 30 rat pups (Roth and Sullivan 2005). Here we provide evidence that the pairing of odor as a conditioned 31 stimulus and β-adrenergic activation in the aPC as an unconditioned stimulus generates early odor 32 preference learning. β-adrenergic blockade in the aPC prevents normal preference learni...
متن کاملOdor specificity of habituation in the rat anterior piriform cortex.
Exposure to odorants results in a rapid (<10 s) reduction in odor-evoked activity in the rat piriform cortex despite relatively maintained afferent input from olfactory bulb mitral cells. To further understand this form of cortical plasticity, a detailed analysis of its odor specificity was performed. Habituation of odor responses in anterior piriform cortex single units was examined in anesthe...
متن کاملHabituation of odor responses in the rat anterior piriform cortex.
Simultaneous recordings of main olfactory bulb (MOB) and anterior piriform cortex (aPCX) neuron responses to repeated and prolonged odor pulses were examined in freely breathing, urethan-anesthetized rats. Comparisons of odor responses were made between multi-unit recordings of MOB activity and single-unit extracellular and intracellular recordings of Layer II/III aPCX neurons. Odor stimuli con...
متن کاملNMDA receptors in mouse anterior piriform cortex initialize early odor preference learning and L-type calcium channels engage for long-term memory
The interactions of L-type calcium channels (LTCCs) and NMDA receptors (NMDARs) in memories are poorly understood. Here we investigated the specific roles of anterior piriform cortex (aPC) LTCCs and NMDARs in early odor preference memory in mice. Using calcium imaging in aPC slices, LTCC activation was shown to be dependent on NMDAR activation. Either D-APV (NMDAR antagonist) or nifedipine (LTC...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2019
ISSN: 0960-9822
DOI: 10.1016/j.cub.2019.06.041